What is Circular RNA?
  • Circular RNAs are covalently closed single-stranded RNA, naturally produced via back-splicing of pre-mRNA exon(s) in eukaryotic cells
  • Broadly expressed in metazoans, but generally at low levels with cell/tissue-specific patterns
  • Inherent stability with resistance to known exonucleases
  • Can be engineered and produced in vitro via in vitro transcription and circularization
Circular RNA Diagram
Why Circular RNA?
01.
Improved Stability
02.
Tunable Expression
03.
Convenient Manufacturing
04.
Low immunogenicity